PUBLICATIONS

2023

• Seol-Hwa Jeong, Hyun-Kyu An, Shinwon Ha and Seong-Woon Yu. "Distinct Signaling Pathways for Autophagy-Driven Cell Death and Survival in Adult Hippocampal Neural Stem Cells." International Journal of Molecular Sciences 24(9). (2023)

2022

• Hyeri Nam, Younghwan Lee, Boil Kim, Ji-Won Lee, Seohyeon Hwang , Hyun-Kyu An, Kyung Min Chung, Youngjin Park, Jihyun Hong, Kyungjin Kim, Eun-Kyoung Kim, Han Kyoung Choe & Seong-Woon Yu. "Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBα" Nature Communications, 13(1), 1-18. (2022)

2021

• Hye Young Ryu, Leah Eunjung Kim, Hyeonjeong Jeong, Ji-Won Lee, Hyeri Nam, Shinwon Ha, Hyun Kyu An, Hyun Hee Park, Seonghee Jung, Kyung Min Chung, Jiyea Kim, Byung-Hoon Lee, Heesun Cheong, Eun-Kyoung Kim, and Seong-Woon Yu*. “GSK3B induces autophagy by phosphorylating and stabilizing ULK1.” Experimental & Molecular Medicine, epub ahead of print (2021)
  
  

• Klionsky et al, “Guidelines for the use and interpretation of assays for monitoring autophagy.” Autophagy, epub ahead of print (2021)

2020

• Eunhee Kim, Sungwoong Jeon, Hyun-Kyu An, Mehrnoosh Kianpour, Seong-Woon Yu, Jin-Young Kim, Jong-Cheol Rah, and Hongsoo Choi. “A magnetically actuated microrobot for targeted neural cell delivery and selective connection of neural networks.” Science Advances (2020)
  
  

• Hyun-Kyu An, Kyung Min Chung, Hyunhee Park, Jihyun Hong, Ji-Eun Gim, Hyosun Choi, Ji Young Mun, and Seong-Woon Yu*. “CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis.” Autophagy 16:1598-1617 (2020)
  
  

• Seolsong Kim, Nayoun Kim, Seokjae Park, Yoonjeong Jeon, Jaemeun lee, Seung-Jun Yoo, Ji-Won Lee, Cheil Moon, Seong-Woon Yu, and Eun-Kyoung Kim. “Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance.” Autophagy16:1200-1220 (2020)
  
  

• Younghwan Lee, Ji-Won Lee, Hyeri Nam, and Seong-Woon Yu*. “Cx3cr1CreERT2-driven Atg7 deletion in adult mice induces intestinal adhesion.” Molecular Brain13:88 (2020)
  
  

• Seonghee Jung, Hyeonjeong Jeong, and Seong-Woon Yu*. “Autophagy as a decisive process for cell death.” Experimental & Molecular Medicine 52:921-930 (2020)
  
  

• Younghwan Lee, Youngjin Park, Hyeri Nam, Ji-Won Lee, and Seong-Woon Yu*. “Translocator protein (TSPO): The new story of the old protein in neuroinflammation.” BMB Reports 53:20-27 (2020)
  
  

• Seonghee Jung, Seongwon Choe, Hangwoong Woo, Hyeonjeong Jeong, Hyun-Kyu An, Hye Young Ryu, Bo Kyoung Yeo, Ye Won Lee, Hyosun Choi, Ji Young Mun, Woong Sun, Han Kyoung Choe, Eun-Kyoung Kim, and Seong-Woon Yu*. “Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.” Autophagy 16:512-530 (2020)

2019

• Caroline Jeeyeon Hong, Jihye Yeon, Bo Kyoung Yeo, Hanwoon Woo, Hyun-Kyu An, Kyuhyung Kim, and Seong-Woon Yu*. "Fas-apoptotic inhibitory molecule 2 localizes to the lysosome and facilitates autophagosome-lysosome fusion through the LC3 interaction region motif-dependent interaction with LC3." FASEB Journal, 34:161-179 (2019)
  
  

• Sungwoong Jeon, Sangwon Kim, Shinwon Ha, Seungmin Lee, Eunhee Kim, So Yeun Kim, Sun Hwa Park, Jung Ho Jeon, Sung Won Kim, Cheil Moon, Bradley J. Nelson, Jin-Young Kim*, Seong-Woon Yu*. and Hongsoo Choi*. “Magnetically actuated microrobots as a platform for stem cell transplantation.” Science Robotics 4:eaav4317 (2019) (* denotes co-corresponding author)
  
  

• Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Jamie Jeong-min Chu, and Seong-Woon Yu*. “Autophagy mediates astrogenesis in adult hippocampal neural stem cells.” Experimental Neurobiology 28:229-246 (2019)
  
  

• Ji-Won Lee, Hyeri Nam, Leah Eunjung Kim, Yoonjeong Jeon, Hyunjung Min, Shinwon Ha, Younghwan Lee, Seon-Young Kim, Sung Joong Lee, Eun-Kyoung Kim, and Seong-Woon Yu*. “TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FoxO3 and impairs phagocytic capacity of microglia.” Autophagy15:753-770 (2019)
  
  

• Hyunhee Park, Kyung Min Chung, Hyun-Kyu An, Ji-Eun Gim, Jihyun Hong, Hanwoong Woo, Bongki Cho, Cheil Moon, and Seong-Woon Yu*. “Parkin promotes mitophagic cell death in adult hippocampal neural stem cells following insulin withdrawal.”  Frontiers in Molecular Neuroscience 12:46 (2019)
  
  

• Hyo Min Cho, Jae Ryun Ryu, Youhwa Jo, Tae Woong Seo, Ye Na Choi, Jee Min Chung, Bongki Cho, Ho Chul Kang, Seong-Woon Yu, Soon Ji Yoo, Hyun Kim, and Woong Sun. “Drp1-Zip1 interaction regulates mitochondrial quality surveillance system.” Molecular Cell, 73:1-13 (2019)

2018

• Hanwoong Woo, Caroline Jeeyeon Hong, Seonghee Jung, Seongwon Choe, and Seong-Woon Yu*. “Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling.” Molecular Brain, 11:37 (2018) 

2017

• Jae Yeon Kim, Ameer Rasheed, Seung-Jun Yoo, So Yeun Kim, Bongki Cho, Gowoon Son, Seong-Woon Yu, Keun-A Chang, Yoo-Hun Suh, and Cheil Moon. “Distinct amyloid precursor protein processing machineries of the olfactory system.” Biochemical and Biophysical Research Communications, 495:533-538 (2017) 
  
  

• Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Kyung Min Chung, Caroline Jeeyeon Hong, Seong Who Kim, Eun-Kyoung Kim, and Seong-Woon Yu*. “Phosphorylation of p62 by AMP-activated protein kinase (AMPK) mediates autophagic cell death in adult hippocampal neural stem cells.” Journal of Biological Chemistry, 292:13795-13808 (2017) 
  
  

• Seung-Jun Yoo, Ji-Hye Lee, So Yeun Kim, Gowoon Son, Jae Yeon Kim, Bongki Cho, Seong-Woon Yu, Keun-A Chang, Yoo-Hun Suh, and Cheil Moon. “Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer” Cell Death and Disease, 8; e2977 (2017) 
  
  

• Min-Seok Kim, Geun-Hee Lee, Yong-Min Kim, Byoung-Wook Lee, Hae-Yun Nam, U-Cheol Sim, Suk-Jung Choo, Seong-Woon Yu, Jae-Joong Kim, Yunhee Kim Kwon, and Seong Who Kim. “Angiotensin II causes apoptosis of adult hippocampal neural stem cells and cognitive impairment through the activation of AMPK-PGC1a signaling in heart failure.” Stem Cells Translational Medicine, 6:1491-1503 (2017) 

2016

• Bo Kyoung Yeo, and Seong-Woon Yu*. “Valosin-containing protein (VCP) structure, functions, and implications in neurodegenerative diseases.” Animal Cells and Systems, 20:6 (2016) 
  
  

• Seung-Jun Yoo, Bongki Cho, Chanil Moon, Seong-Woon Yu, and Cheil Moon. “Neuroprotective effects of an erythropoietin-derived peptide in PC12 cells under oxidative stress.” CNS & Neurological Disorders-Drug Targets, 15:927-934 (2016) 
  
  

• Tae Seok Oh, Hanchae Cho, Jae Hyun Cho, Seong-Woon Yu, and Eun-Kyoung Kim. “Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression.” Autophagy, 12:2009-2025 (2016) 
  
  

• Ji-Won Lee, Hyeri Nam, and Seong-Woon Yu*. “Systematic analysis of translocator protein 18 kDa (TSPO) ligands on toll-like receptors-mediated pro-inflammatory responses in microglia and astrocytes.” Experimental Neurobiology, 25:262-268 (2016)
  
  

• Kyung Min Chung, Eun-Ji Jeong, Hyunhee Park, Hyun-Kyu An, and Seong-Woon Yu*. “Mediation of autophagic cell death by type 3 ryanodine receptor (RyR3) in adult hippocampal neural stem cells.” Frontiers in Cellular Neuroscience, 10:116 (2016)
  
  

• Jae Ryun Ryu, Caroline Jeeyeon Hong, Joo Yeon Kim, Eun-Kyoung Kim, Woong Sun*, and Seong-Woon Yu*. “Control of adult neurogenesis by programmed cell death in the mammalian brain.” Molecular Brain, 9:43 (2016) 
  
  

• Ji-Won Lee, Eun-Jung Leah Kim, Hyun-Jung Shim. Eun-Kyoung Kim, Won Chan Hwang, Do Sik Min, and Seong-Woon Yu*. “A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation.” Biochemical and Biophysical Research Communications, 474:587-593 (2016) 
  
  

• Hyunjung Min, Yong Ho Jang, Ik-Hyun Cho, Seong-Woon Yu, and Sung Joong Lee. “Alternatively activated brain-infiltrating macrophages facilitate recovery from collagenase-induced intracerebral hemorrhage.” Molecular Brain, 9:42 (2016)
  
  

• Caroline Jeeyeon Hong, Hyunhee Park, and Seong-Woon Yu*. “Autophagy for the quality control of adult hippocampal neural stem cells.” Brain Research, 1649:166-172 (2016) 
  
  

• Bo Kyoung Yeo, Caroline Jeeyeon Hong, Kyung Min Chung, Hanwoong Woo, Kyungchan Kim, Seonghee Jung, Eun-Kyoung Kim, and Seong-Woon Yu*. “Valosin-containing protein is a key mediator between autophagic cell death and apoptosis in adult hippocampal neural stem cells following insulin withdrawal.” Molecular Brain, 9:31 (2016) 
  
  

• Jaemeun Lee, Kyungchan Kim, Seong-Woon Yu, and Eun-Kyoung Kim. “Wnt3a upregulates brain-derived insulin by increasing NeuroD1 via Wnt/b-catenin signaling in the hypothalamus.” Molecular Brain, 9:24 (2016) 
  
  

• Hyun-Jung Shim, Sinwoo Park, Ji-Won Lee, Hye-Jin Park, Seung-Hoon Baek, Eun-Kyoung Kim, and Seong-Woon Yu*. “Extracts from Dendrophanz morbifera leaves have modulatory effects on neuroinflammation in microglia.” American Journal of Chinese Medicine, 44:119-132 (2016) 

2015

• Eun-Jung Kim, and Seong-Woon Yu*. “Translocator protein 18 kDa (TSPO): old dogma, new mice, new structure, and new questions for neuroprotection.” Neural Regeneration Research, 10:878-880 (2015)
  
  

• Kyung Min Chung, Hyunhee Park, Seonghee Jung, Shinwon Ha, Seung Jun Yoo, Hanwoong Woo, Hyang Ju Lee, Seong Who Kim, Eun-Kyoung Kim, Cheil Moon, and Seong-Woon Yu*. “Calpain determines the propensity of adult hippocampal neural stem cells to autophagic cell death following insulin withdrawal.” Stem Cell, 33:3052-3064 (2015)
  
  

• Jae Ho Cho, Jeong Hyang Park, Chang Geon Chung, Hyun-Jung Shim, Keun Hye Jeon, Seong-Woon Yu and Sung Bae Lee. “Parkin-mediated response against infection and wound involve TSPO-VDAC complex in Drosophila.” Biochemical and Biophysical Research Communications, 463:1-6 (2015) 
  
  

• Shinwon Ha, Hye Young Ryu, Kyung Min Chung, Seung-Hoon Baek, Eun-Kyoung Kim and Seong-Woon Yu*. “Regulation of autophagic cell death by glycogen synthase kinase-3b in adult hippocampal neural stem cells following insulin withdrawal.”Molecular Brain, 8:30 (2015) 
  
  

• Hyunjung Min, Jinpyo Hong, Ik-Hyun Cho, Yong Ho Yang, Hyunkyoung Lee, Dongwoon Kim, Seong-Woon Yu, Soojin Lee and Sung Joong Lee. “TLR2-induced astrocyte MMP9 activation compromises the blood brain barrier and exacerbates collagenase-induced intracerebral hemorrhage.” Molecular Brain, 8:23 (2015)